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Amaryl is in a class of drugs called sulfonylureas. It is used to help control blood sugar levels. Amaryl is used with diet and exercise to treat noninsulin-dependent (Type II) diabetes mellitus (NIDDM). Insulin or metformin (Glucophage) may also be used in combination with Amaryl, if necessary.

Take Amaryl exactly as directed on the package or as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Amaryl is usually taken once a day, with breakfast or the first main meal. Never take more of this medication than is prescribed for you.

This drug may cause following serious side effects : an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives). Other, less serious side effects from Amaryl result mostly from blood sugar levels that are either too high or too low. You should be familiar with the symptoms of both high and low blood sugar levels and know how to treat both conditions. Low blood sugar may occur when too much Amaryl is taken, when meals are missed or delayed, if you exercise more than usual, during illness, especially with vomiting or diarrhea, if you take other medications, after drinking alcohol, and in other situations. Low blood sugar has the following symptoms: shaking, headache, cold sweats, pale, cool skin, anxiety, and difficulty concentrating. Keep hard, sugary candy, chocolate, fruit juice, or glucose tablets on hand to treat episodes of low blood sugar. Increased blood sugar may occur when not enough Amaryl is taken, if you eat significantly more food than usual, if you exercise less than usual, if you take other medications, during fever or other illness, and in other situations. High blood sugar has the following symptoms: increased thirst, increased hunger, and increased urination. There may be an increased risk of death due to cardiovascular (heart and blood vessels) complications with the use of Amaryl when compared to the treatment of diabetes with diet or diet plus insulin. Side effects other than those listed here may also occur.

Talk to your doctor about any side effect that seems unusual

Tell you doctor if you have kidney disease, have liver disease, have thyroid disease, have type 1 diabetes, have a serious infection, illness, or injury, or need surgery. Amaryl should not be used without first talking to your doctor if you are pregnant or are planning a pregnancy. As it might passes into breast milk and may affect a nursing infant. Follow diet, medication, and exercise routines closely. Changing any of these things can effect your blood sugar levels. Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment. Tell your doctor and dentist that you are taking this medication before you undergo any surgery.

Tell your doctor of all nonprescription and prescription medication you are using, especially : aspirin or another salicylate such as magnesium/ choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan), or bismuth subsalicylate (Pepto-Bismol), a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Voltaren, Cataflam), etodolac (Lodine), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), and naproxen (Anaprox, Naprosyn, Aleve), a sulfa-based drug such as sulfamethoxazole-trimethoprim (Bactrim, Septra), sulfisoxazole (Gantrisin), or sulfasalazine (Azulfidine), a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil), a beta-blocker such as propranolol (Inderal), atenolol (Tenormin), acebutolol (Sectral), metoprolol (Lopressor), and others, a diuretic (water pill) such as hydrochlorothiazide (HCTZ, Hydrodiuril), chlorothiazide (Diuril), and others, a steroid medicine such as prednisone (Deltasone, Orasone, others), methylprednisolone (Medrol, others), prednisolone (Prelone, Pediapred, others), and others, a phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin, Permitil), prochlorperazine (Compazine), promethazine (Phenergan), and others, phenytoin (Dilantin), isoniazid (Nydrazid), rifampin (Rifadin, Rifamate), or over-the-counter cough, cold, allergy, or weight loss medications. Drugs other than those listed here may also interact with Amaryl.

Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma.

Do not share Amaryl with others.

If you miss an Amaryl dosage, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Store Amaryl at room temperature between 68 and 77 degrees F (20-25 degrees C) away from sunlight and moisture.

The following Informationrmation is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.